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KMID : 1189420010140020231
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2001 Volume.14 No. 2 p.231 ~ p.241
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Studies on Inhibitory Effect of Immediate-Type Allergic Reaction of Mahwang-Shin-Gung-San
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Choe Jeong-Hyeon
Hwang Choong-Yeon
Kim Nam-Kwen
Park Min-Cheul
Kim Jin-Man
Moon Sang-Don
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Abstract
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Mahwang-Shin-Gung-San has been found inhibiting the mast cell-mediated anaphylactic reaction. This report describes an inhibitory effect of Mahwang-Shin-Gung-San (MSGS) on the immediate-type cutaneous allergic reactions. MSGS has concentration -dependently inhibited the ear swelling response induced by compound 48/80 in mouse by intradermal injection. The mast cells in mouse ear tissue undergone ear-swelling response by compound 48/80 were stained by alcian blue/nuclear fast red. MSGS significantly inhibited the compound 48/80-induced degranulation from mast cells in ear tissue. MSGS concentration-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. We also studied the effect of MSGS on mast cell-dependent passive cutaneous anaphylaxis (PCA) activated by dinitrophenyl IgE antibody. MSGS showed potent inhibition of PCA by oral administration. These results indicate that MSGS inhibits immediate-type allergic reactions by inhibition of mast cell degranulation in vivo and in vitro.
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